Preheat your oven to 400°F (200°C) and prepare a baking sheet by lining it with parchment paper or giving it a light coating of cooking spray.
In a mixing bowl, combine the room temperature butter, honey, Cajun spice blend, onion powder, smoked paprika, salt, and black pepper, stirring until the mixture is smooth and well blended.
Pat the salmon fillets dry using paper towels and arrange them skin-side down on the prepared baking sheet. Drizzle the olive oil over the fillets and lightly season with salt and pepper.
Spread the Cajun honey butter mixture generously over the top of each salmon fillet, ensuring an even coating.
Place the baking sheet in the oven and bake for approximately 12-15 minutes, or until the salmon is fully cooked and easily flakes apart when tested with a fork.
Remove the salmon from the oven and allow it to rest for a few minutes. Serve with fresh lemon wedges on the side for an added burst of flavor.