Preheat your oven to 375°F.
In a large bowl, combine the ground beef, garlic powder, onion powder, salt, and black pepper. Mix until well combined.
Add the cheddar cheese and half of the Parmesan cheese to the beef mixture and mix until evenly distributed.
Open the can of biscuit dough and separate it into individual biscuits. Flatten each biscuit into a circle about 4 inches in diameter.
Place a generous tablespoon of the beef mixture in the center of each biscuit. Fold the edges of the biscuit over the filling and pinch to seal tightly.
Place the filled biscuits seam-side down on a greased baking sheet.
In a small bowl, mix the melted butter, minced garlic, Italian seasoning, and remaining Parmesan cheese. Brush this mixture over the tops of the biscuit bombs.
Bake in the preheated oven for 15-20 minutes, or until golden brown.
Remove from the oven and let cool for a few minutes before serving. If desired, sprinkle with chopped parsley for garnish.