In a large mixing bowl, combine ground beef with Cajun seasoning, garlic powder, onion powder, salt, and pepper. Mix gently and form into 4 patties.

Preheat grill to medium-high heat or heat a skillet. Grease the surface to prevent sticking.

Cook patties for 4-5 minutes on one side, then flip and cook for an additional 3-4 minutes. Add cheese during the last minute.

Butter insides of buns and toast on grill or skillet for 1-2 minutes until golden.

Assemble burgers with spicy mayo, cheese, and toppings of choice.